When taking any kind of supplement or medication, it is important to know how and when to take it. This can be an especially important question when asking about nattokinase, because nattokinase is classified as a systemic enzyme, which means it works throughout the body, or "system", to build and maintain overall health. In order for a nattokinase supplement to effectively find its way into the system, it needs to pass through the acidic environment of the stomach in a reasonable amount of time. With this being said, the best time to take nattokinase is on an empty stomach, and preferably with at least 8 ounces of water.... An encapsulated supplement can take anywhere from 15-45 minutes to make its way through the stomach, depending on the individual person. If there is food in the stomach, it can inhibit the pass-through process, and the acidity can even begin to break down the enzymes, minimizing the ability of the nattokinase to assimilate into the body and provide maximum benefit. So, what is considered to be an empty stomach? Arthur Andrew Medical, a leading enzyme supplement brand, suggests at least one hour prior to eating and/or two hours after eating a meal. It should also be noted that it is okay to take nattokinase with coffee, juices, tea, and other supplements. Nattokinase Dosage![]() How much nattokinase to take depends on several factors such as the user's age, health, and a few other factors. An individual that is looking to take a nattokinase supplement for general health and prevention will most certainly take a lower dosage than someone that has a more serious existing condition. Be sure to follow the guidelines on a product label, especially if it states a maximum dosage, if you are unsure. At this time there is not enough scientific information to determine an appropriate range of doses for nattokinase, so keep in mind that natural products are not always necessarily safe, and understanding the proper dosages can be important. Once again, be sure to follow relevant directions on product labels, and consult your pharmacist, physician or other healthcare professional prior to using.
58 Comments
Bruce Winter
11/1/2019 09:56:22 pm
I've been taking natto miso for years with supplements after the 1st meal. Now I'm seeing advice to take nattokinase on an empty stomach. Yes, it's a food and not a capsule so I'm wondering if I'm negating the benefits of the enzyme not taking it in non-food form. I just turned 80 and the low BP and blood work always draws comments.
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Hi Bruce...you are still getting the benefits of natto, but in supplement form, nattokinase products are optimal when taken away from food (30-45 minutes before a meal, or 2 hours after a meal). This allows the enzymes to enter the body without being "distracted" by food nutrients.
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JJ
9/7/2020 11:33:26 am
I have been taking nattokinase 2000FU 2-3X/day on empty stomach for a DVT in lower leg... with very good results... much less swelling and pain in only a week. I refused taking Eliquis or Warfarin, after a ton of reading... much to my Doctor's anger.
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JJ
9/10/2020 11:13:31 am
I think you mean taking Nattokinase and Lumbrokinase together... and agree... but I read that taking teh Natto-k and Serrapeptase apart but same day is fine... they seem to do some slightly different things and some similar things... with a DVT, I need anti-coagulation, and the Nattokinase and lumbrokinase I think are much better for that then the serrapeptase... but the Serra works great for the associated inflammation and pain, now much reduced...
JJ
9/10/2020 11:41:31 am
Got it... any dosage recommendations? think the serrapeptase really needs to be enteric coated?
Lisa Samuelsen
3/16/2021 07:20:02 am
I am currently taking Lumbrokinase (20mg) first thing in the morning, on an empty stomach. I am now going to be adding Nattokinase (100 mg) to my routine at night, also on an empty stomach. When researching how these supplements should be taken, I read Lumbrokinase is best in morning and Nattokinase us best at night. I don't know if taking both in the same day is over kill or not, but they both seem to have very good benefits and can work on different things.
Hi JJ,
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JJ
9/10/2020 01:03:30 pm
Yes, The DMSO was of benefit... I just worry about it accentuating the effects/power of the nattokinase or lumbrokinase...
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JJ
9/10/2020 04:51:06 pm
Hi, John, another question... I read that 1-2 glasses of red wine help thin the blood and help prevent clot formation.
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JJ
9/11/2020 09:59:51 am
That is great news... I really enjoyed my small glass of red with lunch...
Brian Moala
3/9/2021 07:50:38 am
Can you take Nattokinase and Horse Chestnut extract together
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JJ
3/9/2021 08:39:25 am
I am not very familiar with Horse Chestnut, but since it seems to have blood thinning properties, I would not take with nattokinase... which also has blood thinning properties... depending on what you are trying to solve, I would consider lumbrokinase instead... I have not posted here for a while, but I switched to the Boluoke brand of lumbrokinase on the recommendation of my NMD, and with serrapeptase, it defeated my DVT (blood clot) in a bit more than 3 months... FAR better than warfarin or Eliquis would have done, without the risk.
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3/15/2021 09:59:56 pm
I have been taking Nato Kinase for 2 years now, I have been taking 2000 FU + K2 MK-7with Natokinase 100mcg and I just started to take Heal -n- SOOTHE byLiving well can you look at this product online and the ingrediants it's a systemic enzyme blend but I am worried about the product I take the Nato at bedtime and the heal and soothe 2 in the am and one more in the afternoon. But I am wondering if together with the Nato is it safe because the Heal & soothe has got also blood thinning properties in it. I had auto accident in 2018 and have had pain ever since. So that is why I am taking the the Heal & soothe. Today is the 2nd day on it and it already is helping. can you e-mail me back. Thanks so much Kat
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JJ
3/16/2021 08:29:15 am
Hi, Kat, I think the only thing in your heal n soothe that thins blood is ginger. IMO, that stuff is WAY overpriced... I recommend buying Devil's claw and bromelain individually ( I use Swansons or Ebay)... and adding 40-80,000 spu serrapeptase to that mix, empty stomach... then you save a ton... get a stronger dose of both the DC and Brom, and don't get the ginger... and add a great anti-inflammatory and healer in serrapeptase.
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Michael
5/15/2021 03:37:36 am
I have a family history of heart disease and a coronary calcium scan show some build up on the left side. My blood pressure is also high. I’ve been working on my diet and fasting for 18 hours daily. Around 16 hours into the fast I take 8,000 fu of Nattokinase in hopes that it will help my arteries. Is there any negative to taking this in a fasted state?
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JJ
5/15/2021 07:14:52 am
I am not a Doctor... but... IMO...I think Nattokinase is supposed to be taken on an empty stomach, otherwise it becomes an expensive digestive enzyme... fasting means empty stomach, so no problem.
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Glenn
9/9/2021 09:15:25 am
Thanks for all of your helpful comments. Can you tell me who your naturopath is? I want to clear my arteries but am confused by how much of what to take etc. Thanks
Bruce winter
9/9/2021 12:58:26 pm
Glenn, I don't have a naturopath I do my own research. I take natto miso which was in supermarkets in Hawaii. Now a friend ships me a box every few months. No problem being room temp for a few days. Or probably longer.
JJ
9/9/2021 01:12:38 pm
Sure, Glenn... again, I am not a doctor, so this is not medical advice... but it depends, IMO, on the amount of clogging you currently have in your arteries... your Cardiologist should be able to do tests to tell you that... for MY blood clot/DVT... I took up to two 20mg Lumbrokinase (Blouoke brand) three time/day... and 80,000 SPU of Serrapeptase daily... always on empty stomach... and waited 30-60 minutes after before eating. That was for a serious, even life threatening condition... for maintenance now, I take one 20mg lumbrokinase (either Boluoke or Doctors Best brand) twice a day... and 40,000-80,000 SPU Serrapeptase daily... it is important, IMO to buy enteric coated products.
glenn
9/10/2021 05:48:22 am
hi j.j. thanks for your reply - in your above post you said you have a good naturopath m.d. i was wondering if i could have his/her name & contact info. many thanks
JJ
9/10/2021 08:52:07 am
Oops! His name is Dr. Jorge Cochran NMD in Tucson, 520-546-3233 he now works with a NP that can prescribe drugs that he cannot. GL to you!
Susan
6/7/2021 06:46:24 am
Good day.
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JJ
6/7/2021 07:00:44 am
Hello, Susan,
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Michelle Kauler
8/1/2021 05:23:10 pm
Is it ok to take Nattokinase as we as olive leaf extract?
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JJ
8/1/2021 06:12:14 pm
I am no Doc... but I doubt they would interact... BUT... I recommend not taking them at the same time... all such enzymes as nattokinase should be taken on an empty stomach... alone.
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Bradley
8/2/2021 04:15:23 pm
What JJ said is good advice...There aren't any known interactions between the two, but always best to take enzyme supplements (unless it's a digestive enzyme supplement) away from foods and other such dietary products. Doing this will increase the efficiency and absorption of both the nattokinase and the olive leaf extract. All the best!
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Vera Osborn
8/9/2021 01:32:52 pm
I suffered a stroke in 2017. I've been on several BP medicines, none of which helped, just made my pressure go very low and caused me dizziness and I was unable to function. I got off of them and now taking Hawthorne berry. But, I need something else to manage my pressure. It goes up to 175/64, and I that's not good. Can take Nattokinaise? I'm 85 yrs old and generally very healthy.
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JJ
8/9/2021 01:52:03 pm
I am not a doctor... keep that in mind... I would assume you are on blood thinners... so nattokinase may not be a great fit... or serrapeptase... if NOT on blood thinners, they IMO, would be helpful. I think lumbrokinase might do you a lot of good... it supposedly doesn't have the bleeding risk that the others do...
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Vera Osborn
8/9/2021 04:36:47 pm
I am not on blood thinners. My doctor put me HCTZ 12.5mg and Simvastatin 20mg. That made my pressure after a time, very low. I stayed on Simvastatin for my Cholesterol. I was then put on Losartan 50mg/ HCTZ 12.5mg. At first it worked very well, my BP was consistent for a while. Then it started going very low, and I was having the same problem again. So I stopped taking anything, except Hawthorn Blend. I don't feel dizzy but sometimes I feel lightheaded. But that doesn't normalize my BP. I know I should take something because I get a pain in the left side of my head below my ear. It comes and goes. My Blood workup has been very good. I have to keep my pressure under control because I have high pressure in my eye, for which I use eyedrops. (Cataracts removed) I know you are not a doctor, but can you just tell me, can I possibly benefit from Nattokinaise?
JJ
8/9/2021 04:54:09 pm
The Hydrochlorothiazide (HCTZ) could cause low BP, if you got to a point that you did not need a diuretic anymore... was your use monitored closely?
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jan gridley
10/1/2021 08:13:51 pm
My husband had a ischemic stroke recently. He took a prescription blood thinner for 90 days along with aspirin. Now that he's off blood thinner & aspirin, we are trying nattokinaise. 1 in a.m & 2 bedtime. Problem is he refuses to give up his 6 oz. Of milk at bedtime. Will that negate the natto's effectiveness.
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JJ
10/1/2021 08:34:30 pm
Hmmmmm... again, I am NOT a doctor, so do your own research... but... I am surprised that your husband was taken off blood thinners after only 90 days... I would HOPE that was due to them confirming his blood clot was completely gone? Perhaps his stroke was "provoked" and the risk is now gone? Unlikely...
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jan gridley
1/10/2022 03:45:15 pm
No, he's not vaxxed, doesn't intend to. What brand of lumbrokinase do you recommend?
JJ
1/10/2022 04:34:01 pm
I took Boluoke brand Lumbrokinase, but I think Dr's Best is probably just fine, and much less.
Lakhwinder
11/8/2021 08:38:45 pm
Can u take nattokianse and probiotic together before go to bed.
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Bradley
11/9/2021 02:18:45 pm
Prior to bedtime is a good time to take supplements like these because they are generally recommended to be taken away from food. I am not aware of any interactions between the two.
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JJ
11/9/2021 02:39:16 pm
Nattokinase needs to be taken on an empty stomach... I don't know about combining with probiotics, but I wouldn't...
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RK
5/17/2022 12:20:14 pm
I have a hard time swallowing capsules. Can I open up the nattokinase and mix it into some liquid and take it that way?
Hi RK,
Deedee
11/28/2021 08:19:08 am
What is the big difference between lumbrokinase and nattokinase? Every time I have been vaccinated my d dimer goes up which is terrifying. Is this due to the spike protein and what is that relationship to clotting? The rest of my blood tests are ok, and I actually git a CT scan after the 1st vaccine and all was fine. It does cause great anxiety and eventually, it does resolve itself. Trying to figure out how much nattikonase to take and if U should switch to lumbrokinase. Earth worms?? I also take 1-3 g of fish oil and curcumin. Both are said to help to thin blood. I have high BP and noticed to recommend lisinopril. Why lisnopril? Why Hytrin? The side effects from BP meds have horrific. Got tachy cardia from htz because can’t keep hydrated because any liquid I drink is quickly removed. I and this vaccine also has its issues. Trying to balance it all out.
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JJ
11/28/2021 09:16:06 am
I am NOT a Doctor... but have done a lot of reading on these enzymes...
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Kristine
12/20/2021 07:25:43 pm
"Personally, I would not combine LK with NK... but would take serrapeptase with either."
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JJ
12/20/2021 08:51:37 pm
Remember, I am no Doc...
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Kristine
12/21/2021 08:07:10 pm
Okay good points, thanks.
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Jay
1/9/2022 07:27:00 am
Started 100mg NK. I noticed that the multi/v I’m taking has high E in it. 67mg of d alpha tocopherol succinate. Any cause for concern, or just lower the dosage of the synthetic E ?
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Maurits de vries
2/11/2022 03:05:03 am
I take one Natto capsule everymorning on a empty stomach, and right after that I take one glass of Diatomaceous earth. Now I`m wondering can the particles in the Diatomaceous earth harm the enzymes? or is that not possible?
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JJ
2/11/2022 08:42:29 am
I think taking the DE right after the natto (you meant nattokinase?) capsule would completely negate any benefit... IMO, the DE would absorb the nattokinase or prevent its absorption. IF you really mean natto, not nattokinase, that would be even more likely to be rendered useless.
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Maurits de vries
2/11/2022 01:17:05 pm
Thank you for your comments
Debbie Gonzalez
2/16/2022 09:08:19 pm
Hi there,
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RT
2/25/2022 06:51:52 pm
i have enjoyed everyone's honest opinion and sharing of their medical condition me personally i had a lung embolism blood clotting and had some clots removed but after 6 months of taking Eliquis 5mg 2x a day they have not dissolved the clots and the problem with the medical community they are trained to give you a prescription that may or may not work and more importantly cause you more harm so now i am on my own quest to find solutions to my own condition and it has been helpful in hearing from you all even though we are not doctors we can at least give our honest opinions and i sincerely thank you all especially you JJ because you let me see that i am on the right track.
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JJ
2/26/2022 08:40:23 am
My pleasure, RT, I am glad you are going in the right direction. It is sad that Cardiologists do not recommend Lumbrokinase along with drugs like Eliquis (which do nothing to dissolve a clot)... but... if they keep your clot in place, very slowly dissolving... they make far more PROFIT.
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T.S.
3/27/2022 12:59:57 pm
I'm old. (83) In my past I've had BOTH corotid arteries surgically scrapped out. Both ops were a success. I have no complaint concerning the surgeon nor the ops themselves. I've also had one heart attack resulting in a stent. (not medicated) I used to smoke and as a result Mr. Emphysema knows my name. But that was then and back then I knew NOTHING of serrapeptase nor nattokinase. If I did I would have taken steps to prevent a reoccurrence. However, I am showing symptoms from ALL 3 areas telling me the crud is back. At my age I am NOT a good surgical risk. (Not that I would.) Here's my plan of action: (Due to my schedule I can only carve out 2 "time windows.") When I wake: 250,000 IU serrapeptase and 2000 FU nattokinase. I repeat the procedure every 12 hours thereafter. If anyone has any suggestions toward a better plan I'm all ears. Thank you.
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JJ
3/27/2022 01:25:27 pm
You plan seems sound... personally, I would exchange nattokinase for lumbrokinase... the strong dosage of both serrapeptase and nattokinase might thin the blood (anticoagulant anti platelet action) a bit too much... and lumbrokinase is many times stronger than nattokinase. I recommend no aspirin if you stick with your plan and don't switch.
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Russ
4/3/2022 08:45:01 am
I was recently diagnosed with Afib and have had one additional episode over a 5 month period of time. Prior to this I did have a brain stroke 14 years ago. I am now 75. I was maintained an Plavix following the stroke with no side effects. After the Afib diagnosis I was told to stop the Plavix and prescribed Eliquis. I could not tolerate Eliquis with many side effects. In the meantime, after talking with my local pharmacist, he suggested I try a quality Nattokinase (DaVinci Labs). I take one 150 mg a day with absolutely no side effects.
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JJ
4/3/2022 11:54:55 am
Well... unfortunately Afib is really tough to treat naturally... beyond any expertise I may have... I will say though... that nattokinase and serrapeptase, especially together, like in your DaVinci supplement (a good one, IMO) can cause blood thinning... when combined with a prescription blood thinner/anticoagulant,,, it might be too much... I worry about a hemorrhagic stroke... make darn sure your MD (and pharmacist) knows about you taking them together... I bet he says NO.
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