 When taking any kind of supplement or medication, it is important to know how and when to take it. This can be an especially important question when asking about nattokinase, because nattokinase is classified as a systemic enzyme, which means it works throughout the body, or "system", to build and maintain overall health. In order for a nattokinase supplement to effectively find its way into the system, it needs to pass through the acidic environment of the stomach in a reasonable amount of time. With this being said, the best time to take nattokinase is on an empty stomach, and preferably with at least 8 ounces of water....
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